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SignalPath LNPs

We leverage novel lipids that are biodegradable and safe, with a tailored immunogenic profile. Then, we use proprietary formulations to combine components into functionalized SignalPath LNPs.

We leverage novel lipids that are biodegradable and safe, with a tailored immunogenic profile. Then, we use proprietary formulations to combine components into functionalized SignalPath LNPs.

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SignalLock RNA

To develop SignalLock RNA, we begin with our microRNA database, correlating thousands of natural microRNAs across hundreds of tissues like a heat map. We use proprietary methods, including the use of AI-driven software, to generate designs that will encrypt mRNA, so it can distinguish between tissues. We further use AI/ML-driven in silico prediction that generates designs for the mRNA sequence that makes up the circuit.

SignalLock RNA enables a level of selectivity that makes genetic medicines safe enough for widespread use.

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SignalScript RNA

To overcome potency and durability challenges, we’re engineering next generation self-replicating and circular RNA with greater strength and persistence.

We create them using novel sequences, built with AI, high throughout screening, and synthetic biology. We produce thousands of versions of these tools with different expression and immunogenicity so we can tailor them to specific indications and tissue types.

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End-to-End mRNA Solutions that Unlock the Future of Genetic Medicine

Strand Signal Stack has taken complex mRNA solutions from design to production to patients.

Technology

Strand Signal Stack

SignalPath LNPs

SignalLock RNA

SignalScript RNA

Our suite of therapeutic design tools works like a flywheel to overcome the targeting, safety, and potency challenges that have been limiting the reach of genetic medicines.

signalpath LNP precision
signallock rna selectivity
signalscript rna durability

SignalPath LNPs

We’re re-imagining LNP construction with novel lipids, novel formulations, and novel targeting moieties. Together, these innovations enable us to create SignalPath LNPs that deliver payloads to tissues throughout the body.

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SignalLock RNA

To ensure that protein payloads only express in target cells, we’ve genetically programmed logic circuits consisting of microRNA-sensors that control the location, timing, and intensity of protein expression.

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SignalScript RNA

To overcome potency and durability challenges, we’re engineering next generation self-replicating and circular RNA with greater strength and persistence.

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Manufacturing mRNA at Scale

Strand Manufacturing

>95%

Full Length

Industry-Leading CDMO

38%

Full Length

To reach large patient populations, we’re working with our GMP partners to manufacture purer, longer-stranded mRNA at a scalable cost.

Longer mRNA enables us to create our self-replicating and circular SignalScript RNA, as well as our SignalLock RNA encryption.

CLINICAL EXECUTION

Our Genetic Medicines are Showing Responses in Patients

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